Keratin 16

KRT16
Identifiers
Aliases	KRT16, CK16, FNEPPK, K16, K1CP, KRT16A, NEPPK, PC1, keratin 16
External IDs	OMIM: 148067; MGI: 96690; HomoloGene: 21145; GeneCards: KRT16; OMA:KRT16 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,615,899 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,139,728 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; hair follicle; ; buccal mucosa cell; ; amniotic fluid; ; skin of abdomen; ; skin of leg; ; periodontal fiber; ; cervix epithelium; ; body of tongue; ; epithelium of esophagus;
	Top expressed in
	lip; ; middle ear; ; epidermis; ; Eustachian tube; ; zone of skin; ; olfactory system; ; corneal epithelium; ; urethra; ; vagina; ; mandibular molars;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of cytoskeleton; protein binding; structural molecule activity;
Cellular component	extracellular exosome; cytoskeleton; intermediate filament; nucleus; cytosol;
Biological process	morphogenesis of an epithelium; hair cycle; keratinocyte migration; human ageing; cell population proliferation; inflammatory response; negative regulation of cell migration; innate immune response; cytoskeleton organization; keratinocyte differentiation; epidermis development; intermediate filament cytoskeleton organization; establishment of skin barrier; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3868
	16666
	ENSG00000186832
	ENSMUSG00000053797
	P08779
	Q9Z2K1
	NM_005557
	NM_008470; NM_001313958
	NP_005548
	NP_001300887; NP_032496
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin 16 is a protein that in humans is encoded by the KRT16 gene.^[5]^[6]^[7]

Keratin 16 is a type I cytokeratin. It is paired with keratin 6 in a number of epithelial tissues, including nail bed, esophagus, tongue, and hair follicles. Mutations in the gene encoding this protein are associated with the genetic skin disorders including pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186832 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053797 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rosenberg M, RayChaudhury A, Shows TB, Le Beau MM, Fuchs E (February 1988). "A group of type I keratin genes on human chromosome 17: characterization and expression". Mol. Cell. Biol. 8 (2): 722–36. doi:10.1128/mcb.8.2.722. PMC 363198. PMID 2451124.
^ Rosenberg M, Fuchs E, Le Beau MM, Eddy RL, Shows TB (1991). "Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12". Cytogenet. Cell Genet. 57 (1): 33–8. doi:10.1159/000133109. PMID 1713141.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ Shamsher MK, Navsaria HA, Stevens HP, Ratnavel RC, Purkis PE, Kelsell DP, McLean WH, Cook LJ, Griffiths WA, Gschmeissner S (October 1995). "Novel mutations in keratin 16 gene underlie focal non-epidermolytic palmoplantar keratoderma (NEPPK) in two families". Hum. Mol. Genet. 4 (10): 1875–81. doi:10.1093/hmg/4.10.1875. PMID 8595410.