Asam niflumat

Asam niflumat
Data klinis
AHFS/Drugs.comInternational Drug Names
Kode ATC
Data farmakokinetika
Waktu paruh eliminasi2,5 jam[1]
Pengenal
  • Asam 2-{[3-(trifluorometil)fenol]amino}nikotinat
Nomor CAS
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.022.289 Sunting di Wikidata
Data sifat kimia dan fisik
RumusC13H9F3N2O2
Massa molar282,22 g·mol−1
Model 3D (JSmol)
Titik leleh204 °C (399 °F)
  • C1=CC(=CC(=C1)NC2=C(C=CC=N2)C(=O)O)C(F)(F)F
  • InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20) N
  • Key:JZFPYUNJRRFVQU-UHFFFAOYSA-N N
 ☒NcheckY (what is this?)  (verify)

Asam niflumat adalah obat yang digunakan untuk nyeri sendi dan otot. Ia dikategorikan sebagai penghambat siklooksigenase-2. Dalam biologi eksperimental, ia telah digunakan untuk menghambat saluran klorida.[2] Ia juga telah dilaporkan bekerja pada saluran NMDA[3] dan GABA-A[4] serta memblokir saluran kalsium tipe T.[5]

Referensi

  1. ^ "Half life". Drug Bank. Diakses tanggal 5 Januari 2024.
  2. ^ Knauf PA, Mann NA (Mei 1984). "Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system". The Journal of General Physiology. 83 (5): 703–25. doi:10.1085/jgp.83.5.703. PMC 2215658. PMID 6736917.
  3. ^ Lerma J, Martín del Río R (Februari 1992). "Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation". Molecular Pharmacology. 41 (2): 217–22. PMID 1371581.
  4. ^ Sinkkonen ST, Mansikkamäki S, Möykkynen T, Lüddens H, Uusi-Oukari M, Korpi ER (September 2003). "Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug". Molecular Pharmacology. 64 (3): 753–63. doi:10.1124/mol.64.3.753. PMID 12920213.
  5. ^ Balderas E, Ateaga-Tlecuitl R, Rivera M, Gomora JC, Darszon A (Juni 2012). "Niflumic acid blocks native and recombinant T-type channels". Journal of Cellular Physiology. 227 (6): 2542–55. doi:10.1002/jcp.22992. PMC 4146346. PMID 21898399.
Ikon rintisan

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