Serotonin

Serotonin
Ball-and-stick model of the serotonin molecule
Nama
Nama IUPAC
5-Hydroxytryptamine or
3-(2-Aminoethyl)indol-5-ol
Nama lain
5-Hydroxytryptamine, 5-HT, Enteramine; Thrombocytin, 3-(β-Aminoethyl)-5-hydroxyindole, Thrombotonin
Penanda
Model 3D (JSmol)
ChEBI
ChEMBL
ChemSpider
Nomor EC
KEGG
MeSH Serotonin
Nomor RTECS {{{value}}}
UNII
  • InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 checkY
    Key: QZAYGJVTTNCVMB-UHFFFAOYSA-N checkY
  • InChI=1/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
    Key: QZAYGJVTTNCVMB-UHFFFAOYAX
  • C1=CC2=C(C=C1O)C(=CN2)CCN
Sifat
C10H12N2O
Massa molar 176,215 g/mol
Penampilan Bubuk putih
Titik lebur 167,7 °C (333,9 °F; 440,8 K) 121–122 °C (ligroin)[3]
Titik didih 416 ± 30 °C (at 760 Torr)[1]
agak larut
Keasaman (pKa) 10,16 dalam air pada 23,5 °C[2]
2,98 D
Bahaya
Lembar data keselamatan External MSDS
Dosis atau konsentrasi letal (LD, LC):
750 mg/kg (subkutan, tikus),[4] 4500 mg/kg (intraperitoneal, tikus),[5] 60 mg/kg (oral, tikus)
Kecuali dinyatakan lain, data di atas berlaku pada suhu dan tekanan standar (25 °C [77 °F], 100 kPa).
checkY verifikasi (apa ini checkYN ?)
Referensi

Serotonin atau 5-hidroksitriptamina (disingkat 5-HT) adalah suatu neurotransmiter monoamino yang disintesiskan pada neuron-neuron serotonergis dalam sistem saraf pusat dan sel-sel enterokromafin dalam saluran pencernaan. Hormon ini dipercaya sebagai pemberi perasaan nyaman dan senang.[6]

Referensi

  1. ^ Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994–2011 ACD/Labs)
  2. ^ Mazák K, Dóczy V, Kökösi J, Noszál B (April 2009). "Proton speciation and microspeciation of serotonin and 5-hydroxytryptophan". Chemistry & Biodiversity. 6 (4): 578–90. doi:10.1002/cbdv.200800087. PMID 19353542. S2CID 20543931.
  3. ^ Pietra S (1958). "[Indolic derivatives. II. A new way to synthesize serotonin]". Il Farmaco; Edizione Scientifica (dalam bahasa Italia). 13 (1): 75–9. PMID 13524273.
  4. ^ Erspamer V (1952). "Ricerche preliminari sulle indolalchilamine e sulle fenilalchilamine degli estratti di pelle di Anfibio". Ricerca Scientifica. 22: 694–702.
  5. ^ Tammisto T (1967). "Increased toxicity of 5-hydroxytryptamine by ethanol in rats and mice". Annales Medicinae Experimentalis et Biologiae Fenniae. 46 (3, Pt. 2): 382–4. PMID 5734241.
  6. ^ Young SN (2007). "How to increase serotonin in the human brain without drugs". Rev. Psychiatr. Neurosci. 32 (6): 394–99. PMID 18043762.

Pranala luar


Ikon rintisan

Artikel bertopik biokimia ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.