ARTIKELDIGITAL.COM

CCL5
Struktur yang tersedia
PDB	Pencarian ortolog: PDBe RCSB
Daftar kode ID PDB
	1B3A, 1EQT, 1HRJ, 1RTN, 1RTO, 1U4L, 1U4M, 1U4P, 1U4R, 2L9H, 2VXW, 5CMD, 5DNF, 5COY
Pengidentifikasi
Alias	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP, C-C motif chemokine ligand 5
ID Eksternal	OMIM: 187011; MGI: 98262; HomoloGene: 2244; GeneCards: CCL5; OMA:CCL5 - orthologs
Lokasi gen (Manusia)
Kr.	Kromosom 17 (manusia)
Akhir	35,880,793 pb
Pola ekspresi RNA
	Ekspresi tertinggi di
	Granulosit; ; Monosit; ; darah; ; nodus limfa; ; limpa; ; kantung empedu; ; Usus dua belas jari; ; epithelium of colon; ; Umbai cacing; ; Sumsum tulang;
	Ekspresi tertinggi di
	mesenteric lymph nodes; ; limpa; ; superior surface of tongue; ; timus; ; darah; ; Usus kosong; ; Usus dua belas jari; ; subcutaneous adipose tissue; ; Paneth cell; ; right lung;
	Referensi data ekspresi selengkapnya
	; ;
	Data ekspresi referensi lebih lanjut
Ontologi gen
Fungsi molekuler	CCR5 chemokine receptor binding; receptor signaling protein tyrosine kinase activator activity; chemokine activity; protein self-association; CCR4 chemokine receptor binding; phosphatidylinositol phospholipase C activity; protein kinase activity; cytokine activity; CCR1 chemokine receptor binding; phospholipase activator activity; chemokine receptor binding; homodimerisasi protein; chemokine receptor antagonist activity; Ikatan protein plasma; chemoattractant activity; pengikatan protein identik; CCR chemokine receptor binding;
Komponen seluler	sitoplasma; extracellular region; extracellular space;
Proses biologis	leukocyte cell-cell adhesion; positive regulation of cell-cell adhesion mediated by integrin; regulation of T cell activation; positive regulation of smooth muscle cell migration; activation of phospholipase D activity; negative regulation of viral genome replication; positive regulation of ERK1 and ERK2 cascade; positive regulation of innate immune response; cellular response to interferon-gamma; positive regulation of macrophage chemotaxis; calcium ion transport; Eksositosis; positive regulation of calcium ion transport; response to cytokine; regulation of insulin secretion; chemokine-mediated signaling pathway; positive regulation of cellular biosynthetic process; response to virus; positive regulation of monocyte chemotaxis; cellular response to fibroblast growth factor stimulus; neutrophil chemotaxis; response to tumor necrosis factor; negative regulation of T cell apoptotic process; positive regulation of GTPase activity; negative regulation of macrophage apoptotic process; positive regulation of T cell proliferation; positive regulation of phosphorylation; inflammatory response; positive regulation of translational initiation; response to toxic substance; positive regulation of epithelial cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; cellular response to organic cyclic compound; cellular calcium ion homeostasis; protein tetramerization; chemotaxis; positive regulation of homotypic cell-cell adhesion; cellular response to interleukin-1; respons imun; positive regulation of viral genome replication; positive regulation of receptor signaling pathway via JAK-STAT; lipopolysaccharide-mediated signaling pathway; positive regulation of T cell migration; regulation of chronic inflammatory response; positive regulation of smooth muscle cell proliferation; neutrophil activation; protein kinase B signaling; positive regulation of cell migration; positive regulation of natural killer cell chemotaxis; cell-cell signaling; eosinophil chemotaxis; dendritic cell chemotaxis; MAPK cascade; macrophage chemotaxis; positive regulation of T cell chemotaxis; regulation of neuron death; positive regulation of phosphatidylinositol 3-kinase signaling; negative regulation of G protein-coupled receptor signaling pathway; positive regulation of T cell apoptotic process; positive regulation of cell adhesion; negative regulation of chemokine-mediated signaling pathway; monocyte chemotaxis; positive chemotaxis; positive regulation of protein tyrosine kinase activity; cellular response to tumor necrosis factor; positive regulation of activation of Janus kinase activity; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; cytokine-mediated signaling pathway; lymphocyte chemotaxis;
	Sumber:Amigo / QuickGO
Ortologi
	6352
	20304
	ENSG00000271503; ENSG00000274233
	ENSMUSG00000035042
	P13501
	P30882
	NM_002985; NM_001278736
	NM_013653
	NP_001265665; NP_002976
	NP_038681
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

CCL5 (bahasa Inggris: CCL5, Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES)code: en is deprecated ) adalah kemokina peptida yang dikodikasi pada gen CCL5^[4] pada kromosom 17.^[5]

Protein CCL5 mempunyai massa 8 kDa, merupakan sitokina kemotaktik bagi sel T, eosinofil dan basofil.

Bersama dengan hormon IL-2 dan IFN-γ yang disekresi oleh sel T, CCL5 menginduksi proliferasi dan aktivasi beberapa sel NK untuk menjadi sel CHAK (bahasa Inggris: CC-Chemokine-activated killer cellcode: en is deprecated ).^[6]

CCL5 yang disekresi oleh sel T CD8 dikenal sebagai faktor penekan virus HIV.

Rujukan

^ ^a ^b ^c ENSG00000274233 GRCh38: Ensembl release 89: ENSG00000271503, ENSG00000274233 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Donlon TA, Krensky AM, Wallace MR, Collins FS, Lovett M, Clayberger C (1990). "Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12". Genomics. 6 (3): 548–53. doi:10.1016/0888-7543(90)90485-D. PMID 1691736. {{cite journal}}: Pemeliharaan CS1: Banyak nama: daftar penulis (link)
^ Donlon et al. Localization of a human T-cell-specific gene, CCL5 (D17S136E), to chromosome 17q11.2-q12. Genomics 5: 548-553, 1990. PMID 1691736
^ Maghazachi et al., CC chemokines induce the generation of killer cells from CD56+ cells, Eur J Immunol. 1996, 26:315-9. PMID 8617297

Artikel bertopik biokimia ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[refGRCh38Ensembl-1] ENSG00000274233 GRCh38: Ensembl release 89: ENSG00000271503, ENSG00000274233 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1691736-4] Donlon TA, Krensky AM, Wallace MR, Collins FS, Lovett M, Clayberger C (1990). "Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12". Genomics. 6 (3): 548–53. doi:10.1016/0888-7543(90)90485-D. PMID 1691736. {{cite journal}}: Pemeliharaan CS1: Banyak nama: daftar penulis (link)

[5] Donlon et al. Localization of a human T-cell-specific gene, CCL5 (D17S136E), to chromosome 17q11.2-q12. Genomics 5: 548-553, 1990. PMID 1691736

[6] Maghazachi et al., CC chemokines induce the generation of killer cells from CD56+ cells, Eur J Immunol. 1996, 26:315-9. PMID 8617297

[1]

[2]

[3]

[4]

[5]

[6]

CCL5

Rujukan

Content Disclaimer