FLII (FLII, actin remodeling protein ) هوَ بروتين يُشَفر بواسطة جين FLII في الإنسان .[ 1] [ 2] [ 3]
الوظيفة
هذا القسم فارغ أو غير مكتمل. ساهم
في توسيعه .
(يوليو 2018 )
الأهمية السريرية
هذا القسم فارغ أو غير مكتمل. ساهم
في توسيعه .
(يوليو 2018 )
المراجع
قراءة متعمقة
Campbell HD، Schimansky T، Claudianos C، وآخرون (1994). "The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans" . Proc. Natl. Acad. Sci. U.S.A . ج. 90 ع. 23: 11386–90. Bibcode :1993PNAS...9011386C . DOI :10.1073/pnas.90.23.11386 . PMC :47987 . PMID :8248259 .
Campbell HD، Fountain S، Young IG، وآخرون (1997). "Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL". Genomics . ج. 42 ع. 1: 46–54. DOI :10.1006/geno.1997.4709 . PMID :9177775 .
Liu YT، Yin HL (1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J. Biol. Chem . ج. 273 ع. 14: 7920–7. DOI :10.1074/jbc.273.14.7920 . PMID :9525888 . {{استشهاد بدورية محكمة }}
: صيانة الاستشهاد: دوي مجاني غير معلم (link )
Wilson SA، Brown EC، Kingsman AJ، Kingsman SM (1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I." Nucleic Acids Res . ج. 26 ع. 15: 3460–7. DOI :10.1093/nar/26.15.3460 . PMC :147727 . PMID :9671805 .
Fong KS، de Couet HG (1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics . ج. 58 ع. 2: 146–57. DOI :10.1006/geno.1999.5817 . PMID :10366446 .
Davy DA، Campbell HD، Fountain S، وآخرون (2001). "The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases". J. Cell Sci . ج. 114 ع. Pt 3: 549–62. PMID :11171324 .
Campbell HD، Fountain S، McLennan IS، وآخرون (2002). "Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development" . Mol. Cell. Biol . ج. 22 ع. 10: 3518–26. DOI :10.1128/MCB.22.10.3518-3526.2002 . PMC :133791 . PMID :11971982 .
Bi W، Yan J، Stankiewicz P، وآخرون (2002). "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse" . Genome Res . ج. 12 ع. 5: 713–28. DOI :10.1101/gr.73702 . PMC :186594 . PMID :11997338 .
Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . ج. 99 ع. 26: 16899–903. Bibcode :2002PNAS...9916899M . DOI :10.1073/pnas.242603899 . PMC :139241 . PMID :12477932 .
Gevaert K، Goethals M، Martens L، وآخرون (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol . ج. 21 ع. 5: 566–9. DOI :10.1038/nbt810 . PMID :12665801 .
Lee YH، Campbell HD، Stallcup MR (2004). "Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity" . Mol. Cell. Biol . ج. 24 ع. 5: 2103–17. DOI :10.1128/MCB.24.5.2103-2117.2004 . PMC :350567 . PMID :14966289 .
Beausoleil SA، Jedrychowski M، Schwartz D، وآخرون (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . ج. 101 ع. 33: 12130–5. Bibcode :2004PNAS..10112130B . DOI :10.1073/pnas.0404720101 . PMC :514446 . PMID :15302935 .
Gerhard DS، Wagner L، Feingold EA، وآخرون (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . ج. 14 ع. 10B: 2121–7. DOI :10.1101/gr.2596504 . PMC :528928 . PMID :15489334 .
Wang T، Chuang TH، Ronni T، وآخرون (2006). "Flightless I homolog negatively modulates the TLR pathway". J. Immunol . ج. 176 ع. 3: 1355–62. DOI :10.4049/jimmunol.176.3.1355 . PMID :16424162 .
Beausoleil SA، Villén J، Gerber SA، وآخرون (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization" . Nat. Biotechnol . ج. 24 ع. 10: 1285–92. DOI :10.1038/nbt1240 . PMID :16964243 .
Olsen JV، Blagoev B، Gnad F، وآخرون (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell . ج. 127 ع. 3: 635–48. DOI :10.1016/j.cell.2006.09.026 . PMID :17081983 .
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